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Technology Platforms

Epigenic Therapeutics' proprietary technology EPIREG® employs our own artificial intelligence (AI) algorithms to explore and obtain innovative optimized CRISPR-Cas components to regulate target gene(s) expression without changing the sequence of the DNA. Among peer technologies, our platform is capable to overcome the potential risk due to DNA cleavage including off-target effect, short half-life, challenging patient compliance issues and etc. Combining with an innovative lipid nanoparticle (LNP) delivery system, our platform has been proven to precisely and efficiently deliver epigenetic modulation tools to the target cells and tissues in metabolic, cardiovascular, viral hepatitis, ocular, oncology and rare disease models.

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    Epigenetic Modulator Platform
    Our Proprietary Epigenetic Modulator to Regulate Target Genes

    Epigenetic modulation is a key mechanism for gene regulation in almost all organisms. It is stable, heritable and serves as a basis for a single fertilized egg to develop into a multi-organ individual. Epigenic Therapeutics developed an Epigenetic Modulator, a platform that utilizes nuclease-inactivated Cas protein and innate gene pathway to precisely control gene expression to cure diseases without any DNA cutting, nicking or altering.

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    AI algorithm Platform
    Artificial intelligence enhances drug discovery based on epigenetic modulator

    By collecting and internally generating a large amount of experimental data, our company established the corresponding artificial intelligence model. We can use the established AI models to discover new components for the epigenetic modification, predict the delivery specificity, provide the optimal guide RNA and select the best editing targets, so as to accelerate the drug development and improve human health.

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    Novel Nano-Delivery System Platform
    Precision Delivery System: Unlocking the Final Barrier in In Vivo Gene Modulation

    Based on non-viral lipid nanoparticle carriers, we have developed new nano-delivery systems based on epigenetic regulation tools through in-depth analysis of the physiological structure and characteristics of non-human primate models. These systems achieved safe and efficient modulation in large animals. Furthermore, combining with AI-assisted nano-surface characteristic analysis, we have also established a technology platform for surface covalent modification, endowing the nano-formulations with both tissue tropism and cellular targeting properties. These systems have already been applied to current pipelines related to metabolic diseases, hepatitis B virus infection, ophthalmology, and more. We have established a comprehensive technical platform that includes innovative lipid screening libraries, targeted delivery research, formulation optimization for primate models, and pilot process development to ensure the in-depth application of epigenetic modulation tools in in vivo studies.

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    Immune and Stem Cells Platform
    Modulation of immune check point genes to enhance in vivo anti-tumor potency

    Immune and Stem Cells Platform achieved precise DNA methylation and histone modification by EPIREG® to lead to potent and durable silencing of target genes. Simultaneously, the platform enhanced the anti-tumor activity and addressed the traditional gene editing induced chromosomal aberrations. Our technology provides the potential as a potent, durable, and safe strategy for future CAR-T cell therapy.